Tumor-Specific Histo-Blood Group Antigens: Apropos of Two Cases

Cancer cells with immunogenic properties having altered protein glycosylation, modified blood group substances have been widely studied. Due to the genetic instability occurring during carcinogenesis glycosyltransferases may suffer from posttranslation sequence modification. The author describes 2 autopsy cases, where in background of unusual metastatic tumor presentation, incompatible antigenic determinants demonstrated using specific lectins and monoclonal antibodies (mAb). In first case, reported here, a 10-year-old girl developed an acute myeloid leukemia died septic endotoxin shock after successful cytostatic treatment juvenile signet ring cell cancer her colon. At there were no signs except bilateral apple-sized mucinous ovarian (Krukenberg) metastases. While she had erythrocyte phenotype A, adenocarcinoma expressed B lectin/mAb. second 78-year-old female resulted macroscopic sign moderately enlarged, ham hard spleen. Light microscopy revealed adenocarcinomatous infiltration splenic sinusoids. patient O, while spleen reacted Breast Carcinoma Antigen (BioGenex) anti-B Banderiaeasimplicifolia agglutinin I mAb. It proved be case occult, completely regressed breast cancer. Based on these observations expression antigens might occur time time, mostly adenocarcinomas. Accordingly, group-based immuno-oncotherapy could considered some cases.